Print.jpg
Screen Shot 2015-06-27 at 3.09.40 AM.png
Screen Shot 2015-07-12 at 3.57.30 PM.png
Print.jpg

Tissue Regeneration


Mitochondria are the power plants of our cells.  And by harnessing their potential, weUnlock the Future of

Synthetic Biology.

 

SCROLL DOWN

Tissue Regeneration


Mitochondria are the power plants of our cells.  And by harnessing their potential, weUnlock the Future of

Synthetic Biology.

 

The Future of Synthetic Biology

is Regeneration

Not only does BiPlastiq intend to revolutionize the capabilities of Synthetic Biology, we also intend to evolve with it!
— C. Powell (Director of BiPlastiq)

While BiPlastiq presently services the ecosystem for Bio-Fabrication, our executive team has a long-term vision that encompasses the emerging market for Regenerative Therapeutics a field, which will quickly supplant traditional forms of medicine.   

Image a world where bioreactors produce tissue replacements in hours rather than weeks, and where Regenerative Therapies heal patients in weeks rather than months. 

Integrating BiPlastiq into such therapeutic applications will profoundly enhance their efficiency and cost-effectiveness. This is because BiPlastiq enhances the very cells on which Synthetic Biology depends, making energy instantaneously available to cells during their most metabolically-intensive tasks. 

This is the Future of Synthetic Biology...

And BiPlastiq will not only revolutionize today's advancements, but it will also evolve to meet the demands of tomorrow's developers. Let us explore how BiPlastiq might enhance the future of Regenerative Therapeutics...

 

Therapeutic Cloning

Therapeutic cloning utilizes cell-samples from a patient (or donor) to produce replacements for damaged tissues and organs. Eventually, BiPlastiq will enhance the cells contained within such replacement-constructs, allowing bioreactors to produce them at an accelerated rate (and at lower cost). And all these benefits will exist without fear of rejection, since the replacements will be derived from the patient's own cells. 

 

 

Cellular Therapy

Regenerative therapies often engineer cells into treatment carriers. In this context, Cellular Therapy is a regenerative strategy that treats disease (or injury) by introducing engineered cells into afflicted tissues. This therapy requires the harvesting of pluripotent cells from a patient (or donor). Once engineered to treat a specific ailment, these cells are then combined with growth factors to form a serum for the treatment. Upon implantation, these cells will integrate into fatigued tissues, dividing into the cellular replacements needed for recovery. 

BiPlastiq's features will be genetically engineered into the harvested cells, providing both the cell and their progeny with metabolic enhancements.  Once activated by an advance form of Light Therapy, BiPlastiq's modifications will profoundly enhance the therapeutic's effectiveness, dramatically increasing the energy available to these pluripotent cells during the metabolically intensive tasks involved in regeneration.

 

Senescence

Remarkably, BiPlastiq's most profound impact could be in the field of Senescence, which studies the deterioration of tissues resulting from age. Recent studies suggest that this deterioration is somewhat attributable to the attrition (or loss) of cells. Luckily, pluripotent cells continually combat the ravages of aging by repopulating our bodies with cellular replacements. Yet as we age, the population of pluripotent cells within our bodies dwindles, ultimately reducing their regenerative capabilities. Our researchers believe that by promoting the longevity and versatility of these cells, BiPlastiq's enhancements might one day aid in slowing (and even reversing) the effects of senescence.  

Screen Shot 2015-06-27 at 3.09.40 AM.png

Epigenetic Enhancement


Light Therapy activates  Mechanisms, within our mitochondria, which Protect the ion-pistons responsible for Energy Production..

Epigenetic Enhancement


Light Therapy activates  Mechanisms, within our mitochondria, which Protect the ion-pistons responsible for Energy Production..

Epigenetic Enhancement

 

In addition to the previously discussed Optogenetic Enhancements, BiPlastiq has developed a series of utilities for Regenerative Therapeutics, which include Epigenetic Enhancements as well as protocols for Light Transmission. In the following sections, we will discuss each of these components in detail...

 

 

 

 

Low Level (Laser) Light Therapy

Low Level Laser Light Therapy (or Light Therapy) utilizes particular wavelengths of light to activate mechanisms, within our mitochondria, which protect the ion-pistons responsible for energy production.

Why is this important?

As mentioned earlier, mitochondria are the power plants of our cells; and the Electron Transport Chain  is the central process through which our mitochondria convert fuel into energy. Yet as our metabolic demands intensify, the Electron Transport Chain is constrained by increasing levels of nitric oxide. This nitric oxide binds to Cytochrome c Oxidase  an ion-piston that is critical to energy production. Consequently, the nitric oxide impedes the Cytochrome c Oxidase’s access to oxygen; effectively reducing its output.

Yet remarkably, Cytochrome c Oxidase is also a photoreceptor, which means it is capable of capturing the energy of light. This radiant energy displaces the nitric oxide, quickening Cytochrome c Oxidase’s reactions. Ultimately, this phenomenon speeds metabolism. And as a result, treated cells see an immediate increase in their energy production during exposure to Light Therapy.

 

Reactive Oxygen Species

In moderate doses, Reactive Oxygen Species promote the expression of genes known to increase cellular plasticity & metabolism

Enhancing cellular metabolism is not merely a matter of increasing energy production. Ensuring the assimilation of this additional energy also entails stimulating increased cellular activity. In furtherance of this, BiPlastiq's platform includes a suite of Epigenetic Enhancements; the cornerstone of which is activated by Light Therapy. 

How?

As oxygen is metabolized by the Electron Transport Chain, a byproduct known as Reactive Oxygen Species is also produced. Hence, as Light Therapy accelerates the Electron Transport Chain, it also thereby increases the presences of these Reactive Oxygen Species. This spike in Reactive Oxygen Species, in turn, promotes the expression of certain genes, which then cause the cells to become more active and resilient for an extended period of time following Light Therapy. In moderate doses, these epigenetic triggers have been observed to dramatically accelerate rates of regeneration.

 

 

Screen Shot 2015-07-12 at 3.57.30 PM.png

Light Transmission


Mobile Solutions  are essential For those

therapeutic applications,

which require implantable forms of Light Transmission.

Light Transmission


Mobile Solutions  are essential For those

therapeutic applications,

which require implantable forms of Light Transmission.

Light Transmission

Light Transmission is an essential feature of BiPlastiq's platform. We are presently developing cutting-edge protocols to regulate the specialized light sources installed in both bioreactors and clinical applications

Additionally, we are committed to providing our In Vivo developers with the novel strategies for continuing treatment beyond the clinical setting. As such, our platforms for light emission must not only be mobile, but also implantable in order to provide our clients with convenient take-home, outpatient solutions. 

We are currently seeking strategic partnerships in developing specialized:

By embedding LEDs into modern-day cast design, BiPlastiq can enhance tissues regeneration outside of clinical settings.

By embedding LEDs into modern-day cast design, BiPlastiq can enhance tissues regeneration outside of clinical settings.

  • Light Emitting Diodes (LEDs) - implantable light emitters with unique properties that include being wirelessly powered, miniaturized, biocompatible and even biodegradable. 

 

  • Hydrogels - injectable, biodegradable substances that are capable of dispersing light within tissues (in a fashion similar to fiber optics).

 

  • Wearable Protocols - guidelines for designing wearable everyday devices capable of regulating, monitoring, and powering these implantable devices.